The anime has been watched by a large number of television viewers in Japan, helping to raise American football's popularity in the country. The manga and anime have been featured at various times in weekly top ten lists of best-selling in their respective media. In Japan, the Eyeshield 21 manga has sold over 20 million volumes. The whole series was streamed in English by, while Sentai Filmworks licensed the series, with distribution from on DVDs. The anime series was later licensed in North America by as a joint effort with Viz Media and aired on December 17, 2007, on its site, but before its completion, the streaming service was shut down. In North America, the manga was released by from April 2005 to October 2011. The Eyeshield 21 franchise has spawned two (OVAs), audio albums, and other merchandise. The television series first aired on Japan's TV Tokyo network from April 6, 2005, to March 19, 2008. An adaptation consisting of 145 television episodes was co-produced by. The series consists of 333 chapters collected in 37 volumes. The manga was originally serialized in 's from July 2002 to June 2009.

Inagaki chose American football as a central subject of Eyeshield 21 after realizing that it fit perfectly with his idea for the series. The series tells the story of, an introverted boy who joins an club as a, but after being coerced by, turns out to play wearing an and the number 21, under the pseudonym of 'Eyeshield 21'. NFL Rush Original run Ap– MaEpisodes 145 () Eyeshield 21: Christmas Bowl e no Michi Studio Released 2005 Runtime 11 minutes Eyeshield 21 (: アイシールド21,: Aishīrudo Nijūichi) is a Japanese series written by and illustrated. To hide their new `star` player from the eyes of other High Schools, Hiruma encases Sena in a Amefuto helmet with a dark visor and name him Eyeshield #21. Coincidentally, Hiruma Youichi and Kurita Ryukan are looking for a fast running back for their American Football team (Amefuto) and want to put Sena in the team. Since elementary school, he always play the role of the `errand boy` to the extent that he has become swift and fast in his movements. Kobayakawa Sena is a little guy who always get picked on by the bullies in school. Watch Eyeshield 21 Episode 37 English Subbedat Gogoanime. Eyeshield 21 Episode 121 Subtitle Indonesia.

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